Synthesis of enantiopure trisubstituted piperidines from a chiral epoxyaziridine and α-amino esters
نویسندگان
چکیده
منابع مشابه
Synthesis of chiral amino epoxyaziridines: useful intermediates for the preparation of chiral trisubstituted piperidines.
Chiral aminoalkyl epoxyaziridine 1 is synthesized in high yield and diastereoselectivity from L-serine. Ring opening of epoxyaziridine 1 with primary amines is carried out with total chemo- and regioselectivity, affording chiral polyfunctionalized piperidines 8. The structure of these trisubstituted piperidines is established by NMR studies.
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2009
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0010.227